Comprehensive information about the economic situation of a company. SAR100842 was inactive on LPA2, LPA3 and LPA5 receptors up to 10 μM on these receptors (Table S2). Submit new company name now, Maurer, Matthias Johannes Wolfgang Eberhard. Afterwards, 3.15‐M perchloric acid and 20% p‐dimethylaminobenzaldehyde were added and samples were incubated for 20 min at 60°C. Beyond its profibrotic effects and effects on cytoskeleton reorganization, LPA strongly stimulates the motility of human neutrophils, increased the binding of monocytes and neutrophils to human aortic endothelial cells (Idzko et al., 2004), and induced de‐differentiation of vascular smooth muscle cells (Zhou, Niu, & Zhang, 2009). This Declaration acknowledges that this paper adheres to the principles for transparent reporting and scientific rigour of preclinical research as stated in the BJP guidelines for Design and Analysis, Immunoblotting and Immunochemistry, and Animal Experimentation and as recommended by funding agencies, publishers, and other organizations engaged with supporting research. The potency of SAR100842 in this assay was in the same range (~100 nM) as that determined on the calcium response in the same fibroblasts or in CHO expressing LPAR1. As a registered member you see more information about, Details of current and former board members, senior managers and authorised signatories, 2 certified trade register extracts giving full printer-friendly information, As a Premium member you see even more information about, Information on turnover and employee numbers as well as details on the management, Follow an unlimited number of companies, persons and keywords, Graphical network function of companies and persons, 1 credit rating query included (value of CHF 19.00). αSMA and skin thickness were analysed using Kruskal–Wallis test followed by multiple comparisons. Lonza Sales AG is currently active and the industry «Trading with various goods». Bupropion was included as structurally related drug used therapeutically. SAR100842 induced a concentration‐dependent inhibition (mean IC50 237 nM with 95% confidence interval [166–339 nM]) of the LPA 18:1‐induced calcium response (n = 12), confirming that LPA1 receptor is the main driver of the LPA response in systemic sclerosis dermal fibroblasts (Figure 2d). The data and statistical analysis comply with the recommendations of the British Journal of Pharmacology on experimental design and analysis in pharmacology (Curtis et al., 2018). Sehen Sie sich das Profil von Matthias Maurer auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. Raoul Bayard, Jean-Christophe Pierrick Hyvert, Rodolfo José Savitzky, Albert Pereda Miquel, Alexandra Stöbi-Zumsteg, André Goerke. 4031995).Ausgeschiedene Personen und erloschene Unterschriften: Ziegler, Christoph Patrick, von Allschwil, in Basel, Mitglied des Verwaltungsrates, mit Kollektivunterschrift zu zweien.Eingetragene Personen neu oder mutierend: Hyvert, Jean-Christophe Pierrick, von Kölliken, in Freienbach, Mitglied des Verwaltungsrates, mit Kollektivunterschrift zu zweien; Fleischer, Katja, von Saint-Livres, in Zürich, mit Kollektivunterschrift zu zweien. The expression of the different LPA receptors was measured by RT‐PCR in dermal fibroblasts from systemic sclerosis patients (Figure 2a). Lonza Sales AG, in Basel, CHE-109.426.535, Aktiengesellschaft (SHAB Nr. In an attempt to characterize the antagonistic activity of SAR100842 against LPA6 receptors, SAR100842 was tested in human endothelial cells expressing endogenous LPAR2 and LPAR6 and using IL‐6 as marker of LPA6 engagement (Table S3). He is fluent in four languages (German, English, Spanish, French) and as part of his astronaut training, he is also taking intensive language training in Russian and Chinese. L.L., B.L., R.B., M.S., J.P., H.R., A.J., P.J. To determine LPA1 receptor engagement in the Tsk1 model, IL‐6, CCL2 and CXCL1 skin expression was quantified. Maurer applied to the European Space Agency as an astronaut in 2008 with almost 8500 other candidates and was one of ten to pass the selection procedure, but was not initially appointed to the European Astronaut Corps. You are already following 2 companies, persons or keywords. Statistical analyses were performed to evaluate the LPA effect and then for αSMA expression the SAR100842 treatment effect. For human LPAR expression, statistical analyses were performed to evaluate the difference of expression of LPAR1 versus the other LPA receptors. In addition, he has a patent miR‐29 for the treatment of systemic sclerosis issued (US8247389 and EP2331143). For Tsk1 model, 7 animals per grop were analyzed. J.H.W.D. This effect was blocked by pertussis toxin, a Gi/Go protein inhibitor, indicating Gi/Go coupling of the receptor (Figure 2c). Randomization was performed on weight and sex before initiation of treatment and equal number of animals was used for each treatment group. This study was supported by Sanofi. In 2006, Maurer successfully completed an additional course of study in economics at the University of Hagen with a MBA management degree. 9 Jobs sind im Profil von Matthias Maurer aufgelistet. received consultancy fees from Boehringer‐Ingelheim and Thermo‐Fischer, speeking fees and/or educational support from Abbvie, Roche, Pfizer, BMS. Lonza Sales AG, in Basel, CHE-109.426.535, Aktiengesellschaft (SHAB Nr. Legal form: Company limited by shares (AG). LPA (18:1) induced a concentration‐dependent transient increase in cytosolic calcium with an EC50 of 150 ± 50 nM in systemic sclerosis dermal fibroblasts (Figure 2c). Interestingly, H2L5765834 has been reported as a selective LPA1,3,5 antagonist, but to our knowledge its effect has not been investigated in fibroblasts or in a fibrotic context (Williams et al., 2009). 1004728419).Ausgeschiedene Personen und erloschene Unterschriften: Funk, Markus, von Vandoeuvres, in Schindellegi , Mitglied des Verwaltungsrates, mit Kollektivunterschrift zu zweien.Eingetragene Personen neu oder mutierend: Bayard, Raoul, von Varen, in Brig-Glis, Mitglied des Verwaltungsrates, mit Kollektivunterschrift zu zweien. In patients with systemic sclerosis, CCL2 levels are increased in serum, along with enhanced CCL2 expression in the epidermis, inflammatory mononuclear cells, and endothelial cells. Figure S3D: Effect of LPA on the induction of αSMA gene expression. Hydroxyproline was analysed using a one‐way ANOVA followed by multiple comparisons. P.J. The mitochondrial membrane potential was decreased in HepG2 cells by bupropion, MDPV and naphyrone, confirming mitochondrial toxicity. Clinical characterization of patients used for the generation of primary fibroblast cultures (lcSSc = limited SSc / dcSSc=diffuse SSc), Table S2. Group size is the number of independent values, and statistical analysis (n > 5) was done using these independent values (i.e. All fold analyses derived from the different figures are provided with statistical analysis as the Supporting Information. We focused on WNT2 and SFRP4, known to be overexpressed in the skin of systemic sclerosis patients (Wei et al., 2012). Die Gesellschaft kann Liegenschaften erwerben, verwalten und veräussern. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, SAR100842 inhibits functionally active forms of lysophosphatidic acid (LPA). To determine the number of activated fibroblasts (myofibroblasts) as another parameter of skin fibrosis, pictures at ×100 magnification were taken, and spindle‐shaped, αSMA+ cells not part of vascular structures were counted in three randomly chosen HPF per slide. In comparison, methedrone and methylone depleted the cellular ATP pool and induced cytotoxicity at similar concentrations (≥2 mM). Beliebt bei Matthias Maurer Today, Lonza hosted its Annual General Meeting, led by the Chairman of the Board of Directors, Albert M. Baehny. Publication number: HR02-1004825138, Commercial Registry Office Basel-Stadt, (270).

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+ How we made $200K with 4M downloads.

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