(2011). (2003). Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108, Assembly and solution structure of the core retromer protein complex, Norwood, SJ, Shaw, DJ, Cowieson, NP, Owen, DJ, Teasdale, RD and Collins, BM (2011). Understanding these molecular mechanisms will allow us to determine how their dysfunction contributes to disease and how to target them for new therapies. PX-FERM proteins: A link between endosomal trafficking and signaling? Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex. Small angle X-ray scattering of protein complexes regulating membrane trafficking, (2010) Australian Synchrotron Access Program, Endosomal Protein Transport: From Molecular Structures to Biological Function. BioArchitecture, 4 (6), 215-220. doi: 10.1080/19490992.2015.1031950, Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy, Sierecki, Emma, Stevers, Loes M., Giles, Nichole, Polinkovsky, Mark E., Moustaqil, Mehdi, Mureev, Sergey, Johnston, Wayne A., Dahmer-Heath, Mareike, Skalamera, Duka, Gonda, Thomas J., Gabrielli, Brian, Collins, Brett M., Alexandrov, Kirill and Gambin, Yann (2014). Crystal structure of a heptameric Sm-like protein complex from archaea: Implications for the structure and evolution of snRNPs. doi: 10.7554/eLife.01434, Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules, Ghai, Rajesh, Mobli, Mehdi and Collins, Brett M. (2014).
doi: 10.1016/j.devcel.2019.07.021. STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?. Survey of the year 2009: applications of isothermal titration calorimetry. PX family proteins at the interface between intracellular trafficking and signalling, Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis. Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α.
BETHESDA: AMER SOC CELL BIOLOGY. His team is now focused on understanding how discrete molecular interactions between proteins and lipids control these processes in human cells. Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. eLife, 7 e35898. Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Journal of Cell Science, 128 (7), 1269-1278. doi: 10.1242/jcs.167866, Phosphoinositide binding by the SNX27 FERM domain regulates localisation at the immune synapse of activated T-cells, Ghai, Rajesh, Tello-Lafoz, Maria, Norwood, Suzanne J., Yang, Zhe, Clairefeuille, Thomas, Teasdale, Rohan D., Mérida, Isabel and Collins, Brett M. (2015).
Cell Reports, 9 (1), 206-218. doi: 10.1016/j.celrep.2014.08.059, Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins, Teasdale, Rohan D. and Collins, Brett (2014). Always feel free to contact the staff for more information, and also with your own research ideas. STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies? (2002). 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia Conference, 23-27 August 2015. The structure and function of the retrometer protein complex. (2013). He is the recipient of 3 prestigious fellowships, including a previous Career Development Award from the National Health and Medical Research Council and a Future Fellowship from the Australian Research Council, and was awarded the University of Queensland Research Excellence Award in 2008.
Faulty proteins are known to cause the development of neurodegenerative conditions such as Parkinson’s and Alzheimer’s disease, and muscular dystrophy. Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. (2014). Teasdale, Rohan D. and Collins, Brett M. (2014) Introduction to special issue on endosome dynamics. Developmental Cell, 54 (1), 75-91.e7. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation. Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Answers, School of Information Technology and Electrical Engineering, A/Prof Brett Collins - IMB Group Leader profile, UQ
Traffic, 5 (2), 79-88. doi: 10.1111/j.1600-0854.2004.00158.x, Adaptors for Clathrin Coats: Structure and Function, Owen, David J., Collins, Brett M. and Evans, Philip R. (2004). Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Developmental Cell, 4 (3), 321-332. doi: 10.1016/S1534-5807(03)00037-6, Molecular architecture and functional model of the endocytic AP2 complex, Collins, Brett M., McCoy, Airlie J., Kent, Helen M., Evans, Philip R. and Owen, David J. Survey of the year 2008: Applications of isothermal titration calorimetry.
Associate Professor Collins was awarded his PhD in 2001 and has published over 75 papers including in Cell, Nature, Nature Structural and Molecular Biology, Developmental Cell, and The Proceedings of the National Academy of Sciences USA, altogether cited more than 3100 times.
Collins, B. M. (2008). Nature Cell Biology, 21 (10), 1219-1233. doi: 10.1038/s41556-019-0393-3, Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes, Ugrankar, Rupali, Bowerman, Jade, Hariri, Hanaa, Chandra, Mintu, Chen, Kevin, Bossanyi, Marie-France, Datta, Sanchari, Rogers, Sean, Eckert, Kaitlyn M., Vale, Gonçalo, Victoria, Alexia, Fresquez, Joseph, McDonald, Jeffrey G., Jean, Steve, Collins, Brett M. and Henne, W. Mike (2019). Collins, BM and Owen, DJ (2004). doi: 10.1371/journal.pone.0020420, Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens, Mangold, Sabine, Wu, Selwin K., Norwood, Suzanne J., Collins, Brett M., Hamilton, Nicholas A., Thorn, Peter and Yap, Alpha S. (2011).